Vote!

Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model

In conclusion, imidazoquinoline treatment enhances T-cell lymphocyte infiltration and proinflammatory cytokine production within established mouse RCC tumors, while suppressing tumor growth via induction of cancer cell apoptosis. These findings support a therapeutic role for imidazoquinoline in RCC. (Source: Clinical and Developmental Immunology)...

read more...

Published By: MedWorm/DeathRecovery - Wednesday, 22 February

• Older News
• Vote! FOXO3a Activates NF-{kappa}B [Signal Transduction] MedWorm/Stress (2 days ago) - FOXO3a, a member of the Forkhead box O (FoxO) transcription factor family, is believed to...
• Vote! Regulation of MDM2 and p53 by L11 and ARF [Cell Biology] MedWorm/Stress (2 days ago) - The ARF tumor suppressor protein activates p53 in response to oncogenic stress, whereas ribosomal protein...
• Vote! The Role of Mitochondria in Pediatric Oxygenation MedWorm/Stress (2 days ago) - Mitochondria play multiple roles in the cell, including maintaining energy homeostasis in response to environmental...
• Vote! Oxidized Phospholipids in TNF{alpha} Apoptosis [Cell Biology] MedWorm/DeathRecovery (2 days ago) - TNFα generates reactive oxygen species (ROS) at the cell surface that induce cell death, but...
• Vote! Leukotoxin Causes Lysosomal Mediated Cell Death [Cell Biology] MedWorm/DeathRecovery (2 days ago) - Leukotoxin (LtxA) is a protein toxin that is secreted from the oral bacterium, Aggregatibacter actinomycetemcomitans....
  • Regulation of MDM2 and p53 by L11 and ARF [Cell Biology]
  • The Role of Mitochondria in Pediatric Oxygenation
  • Oxidized Phospholipids in TNF{alpha} Apoptosis [Cell Biology]
• Vote! Prostaglandin Receptor EP1 Enhances COX-2 Degradation [Cell Biology] MedWorm/DeathRecovery (2 days ago) - The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals...
  • Regulation of MDM2 and p53 by L11 and ARF [Cell Biology]
• Vote! Caveolin-1 and Paclitaxel Responsiveness [Cell Biology] MedWorm/DeathRecovery (2 days ago) - Paclitaxel, an anti-microtubule agent, is an effective chemotherapeutic drug in breast cancer. Nonetheless, resistance to...