Melatonin protects against isoproterenol‐induced alterations in cardiac mitochondrial energy metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats
AbstractThe present study was undertaken to explore the protective effect of melatonin against isoproterenol bitartrate (ISO)‐induced rat myocardial injury and to test whether melatonin has a role in preventing myocardial injury and recovery when the ISO‐induced stress is withdrawn. Treatment of rats with ISO altered the activities of some of the key mitochondrial enzymes related to energy metabolism, the levels of some stress proteins and the proteins related to apoptosis. These changes were found be ameliorated when the animals were pre‐treated with melatonin at a dose of 10 mg /...
Published By: MedWorm/DeathRecovery - Wednesday, 22 February
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