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Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression
The C‐terminal Src kinase (Csk) is an essential signaling factor guiding CNS development. In the adult brain, Csk‐mediated control of Src may also modulate glutamatergic synaptic transmission and N‐methyl‐D‐aspartate receptor (NMDAR)‐dependent synaptic plasticity. The regulation of NMDA‐dependent plasticity by a myriad of kinase cascades has been investigated intensively during spatial and fear learning, while little is known about the regulatory kinases and role of NMDA‐dependent plasticity during equally critical forms of social learning. We assessed social memory in Csk(+/+) and Csk(+/‐) mice backcrossed onto 129P2, an inbred strain with wild...
Published By: MedWorm/Autism - Wednesday, 22 February
