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Diethyl Phthalate Enhances Apoptosis Induced by Serum Deprivation in PC12 Cells
In this study, to examine the mechanism of diethyl phthalate toxicity to cells, the effects of diethyl phthalate on apoptosis in a PC12 cell system were investigated by assaying apoptotic factors such as caspase‐3, Bax, cytochrome c, and DNA damage. Diethyl phthalate was shown to enhance the apoptosis induced by serum deprivation according to the results of DNA electrophoresis and TUNEL signal assays, although it could not induce apoptosis itself in the cells. This enhancement was thought to due to an increase of caspase‐3‐like activity. In addition, the expression of...
Published By: MedWorm/Stress - Wednesday, 22 February
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