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A CRM1‐dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF‐κB activity

HSCARG is a newly identified NF‐κB inhibitor that plays important roles in cell growth. Our previous study found that HSCARG could shuttle between the nucleus and cytoplasm by sensing the change in cellular redox states. To further investigate the mechanism of HSCARG translocation and its effect on the regulation of NF‐κB activity, we identified a previously uncharacterized nuclear export signal (NES) at residues 272‐278 of HSCARG that is required for its cytoplasmic translocation. This leucine‐rich NES was found to be mediated by CRM1. More importantly, accumulation of HSCARG in the...

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Published By: MedWorm/Stress - Wednesday, 22 February

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